Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Dissociation constant

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

3.22(±0.03), 25±1°C, titration method, OECD 112, Chamberlain
2.98, potentiometric method, OECD 112, Wollerton

Key value for chemical safety assessment

Additional information

Two experimental values are available for 2-(4-((5-(trifluoromethyl)pyridin-2-yl)oxy)phenoxy)propanoic acid, which is considered to be the relevant ionisable species. One is for the (R)-enantiomer, the second is the racemate; both are equivalent for this endpoint. While both reported values are in reasonable agreement, those from Wollerton et al are selected to maintain dataset consistency, and as they were collected under GLP. However, it is likely those reported by Chamberlain are the more accurate.