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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: citation in a peer reviewd publication

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1981
Reference Type:
secondary source
Title:
1,4-Dichlor-2-nitrobenzol
Author:
BUA
Year:
1991
Bibliographic source:
BUA-Stoffbericht 65, ISBN 3-527-28462-1, VChVerlagsgesellschaft mbH, 8940 Weinheim

Materials and methods

Test guideline
Guideline:
other: interna guideline
Principles of method if other than guideline:
6 male and 6 female rats inhaled the test substance for 7 hours: nominal concentration 47.6 mg/m³/h
GLP compliance:
no
Test type:
other: time-saturation test

Test material

Constituent 1
Chemical structure
Reference substance name:
1,4-dichloro-2-nitrobenzene
EC Number:
201-923-3
EC Name:
1,4-dichloro-2-nitrobenzene
Cas Number:
89-61-2
Molecular formula:
C6H3Cl2NO2
IUPAC Name:
1,4-dichloro-2-nitrobenzene
Test material form:
other: solid
Details on test material:
no data

Test animals

Species:
mouse
Strain:
not specified
Sex:
male/female
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
air
Details on inhalation exposure:
6 male and 6 female rats inhaled the test substance for 7 hours: nominal concentration 47.6 mg/m³/h
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
7 h
Concentrations:
nominal 47.6 mg/m³/h
No. of animals per sex per dose:
6
Control animals:
not specified
Details on study design:
6 male and 6 female rats inhaled the test substance for 7 hours: nominal concentration 47.6 mg/m³/h
Statistics:
no data

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: time saturation test
Effect level:
47.6 mg/m³ air (nominal)
Exp. duration:
7 h
Remarks on result:
other: all animals survived
Mortality:
none
Clinical signs:
other: increased breathing rate, narrow palpebral fissure
Body weight:
normal body weight development
Gross pathology:
no findings

Applicant's summary and conclusion