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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Comparable to guideline study with acceptable restrictions.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: 84/449/EWG B.6(Maximization test according to Magnusson and Kligman)
GLP compliance:
yes
Type of study:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
N,N'-1,6-hexanediylbis(N-(2,2,6,6-tetramethyl-piperidin-4-yl)formamide
EC Number:
413-610-0
EC Name:
N,N'-1,6-hexanediylbis(N-(2,2,6,6-tetramethyl-piperidin-4-yl)formamide
Cas Number:
124172-53-8
Molecular formula:
C26H50N4O2
IUPAC Name:
N,N'-1,6-hexanediylbis(N-(2,2,6,6-tetramethyl-piperidin-4-yl)formamide

In vivo test system

Test animals

Species:
other: gpg,Pirbright White

Study design: in vivo (non-LLNA)

Induction
Concentration / amount:
Conceantration of test material and vehicle used at induction
a) I.C.: 5% in olive oil DAB 9
b) P.C.: 25% in olive oil DAB 9
Concentration of test material and vehicle used for each challenge
a) 10% in olive oil DAB 9
Challenge
Concentration / amount:
Conceantration of test material and vehicle used at induction
a) I.C.: 5% in olive oil DAB 9
b) P.C.: 25% in olive oil DAB 9
Concentration of test material and vehicle used for each challenge
a) 10% in olive oil DAB 9
No. of animals per dose:
Number of animals in test group: 10
Number of animals in negative control group: 10

Results and discussion

In vivo (non-LLNA)

Resultsopen allclose all
Reading:
1st reading
Hours after challenge:
24
Group:
test chemical
Dose level:
10%
No. with + reactions:
0
Total no. in group:
10
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 10%. No with. + reactions: 0.0. Total no. in groups: 10.0.
Reading:
2nd reading
Hours after challenge:
48
Group:
test chemical
Dose level:
10%
No. with + reactions:
0
Total no. in group:
10
Remarks on result:
other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: test group. Dose level: 10%. No with. + reactions: 0.0. Total no. in groups: 10.0.
Reading:
1st reading
Hours after challenge:
24
Group:
negative control
Dose level:
10%
No. with + reactions:
0
Total no. in group:
10
Remarks on result:
other: Reading: 1st reading. . Hours after challenge: 24.0. Group: negative control. Dose level: 10%. No with. + reactions: 0.0. Total no. in groups: 10.0.
Reading:
2nd reading
Hours after challenge:
48
Group:
negative control
Dose level:
10%
No. with + reactions:
0
Total no. in group:
10
Remarks on result:
other: Reading: 2nd reading. . Hours after challenge: 48.0. Group: negative control. Dose level: 10%. No with. + reactions: 0.0. Total no. in groups: 10.0.

Any other information on results incl. tables

LLNA

Maximum concentration not causing irritating effects inpreliminary test : 10%

Signs of irritation during induction :

i .c. : Significant redness, weak

p.c. : Significant redness, weak, crusting, partially broken.

( i.c . : deutliche Rtung, schwaches dem

p.c . : deutliche Rtung, schwaches dem, Krustenbildung, teilsaufgebrochen.)

Applicant's summary and conclusion

Interpretation of results:
other: not classified