Registration Dossier

Administrative data

chronic toxicity: dermal
Data waiving:
study scientifically not necessary / other information available
Justification for data waiving:
a short-term toxicity study does not need to be conducted because a reliable sub-chronic (90 days) or chronic toxicity study is available, conducted with an appropriate species, dosage, solvent and route of administration
Justification for type of information:
Valid repeated dose studies via the oral route as well as toxicokinetic information including dermal absorption studies is available that allows route-to-route extrapolation for dermal exposure. The substance has no local irritating effect and therefore no assessment of possible local effects after repeated dermal exposure is needed.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2-bis(chloromethyl)trimethylene bis(bis(2-chloroethyl)phosphate)
EC Number:
EC Name:
2,2-bis(chloromethyl)trimethylene bis(bis(2-chloroethyl)phosphate)
Cas Number:
Molecular formula:
2,2-bis(chloromethyl)propane-1,3-diyl tetrakis(2-chloroethyl) bis(phosphate)

Results and discussion

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion