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EC number: 809-920-4 | CAS number: 1047637-37-5
- Intradermal induction: very slight to well-defined erythema (grades 1 -2) at 24 and 48 hours in all tst animals, no reactions in control group.
- Epicutaneous induction: very slight erythema (grade 1) with or without very slight oedema (grade 1) noted at 16 test animals after 1 hour, in 5 animals also after 24 hours. Very slight erythema (grade 1) noted in 7 control animals after 1 hour, very slight oedema (grade 1) noted in 1 control group animal after 1 hour.
- Epicutaneous challenge undiluted test substance: very slight erythema (grade 1) noted in 2 test animals after 24 hours, in 1 animal after 48 hours and in none of the animals after 72 hours. No skin reactions in control group at any time.
-Epicutaneous challenge 75% in acetone: No skin reactions were observed in all the challenge sites of test animals and controls at all time points.
- 17% of the test animals (3/18) showed a positive skin reaction at challenge. According to the test guideline this result can be regarded as negative as less than 30% of the animals showed a positive challenge reaction. The test material is therefore not a skin sensitizer under the conditions of this study.
2 animals died during the study for undefined reasons.
Body weight gains of the test group were comparable to those observed in the negative control group.
In a dermal sensitization study, 2,2-bis(chloromethyl)trimethylene bis(bis(2-chloroethyl)phosphate) was tested in female albino Dunkin-Hartley guinea pigs according to OECD Test Guideline No.406 (guinea pig maximisation test). At challenge with the undiluted test substance 3 of 18 animals (17%) showed a slight skin reaction. None reacted positively in the group challenged with 75% of the test substance in acetone. According to the test guideline the substance is not considered a skin sensitizer in this study. Two test animals died during the study for undefined reasons. Body weight gains of the test animals were comparable to those of the negative controls.
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