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Toxicity to soil microorganisms

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Description of key information

NOEC of ≥128 mg/kg soil

Key value for chemical safety assessment

Additional information

Based on Read-Across with 2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate


Inhibition of soil nitrogen transformation by soil micro-organisms has been examined in a study with tris[2-chloro-1-(chloromethyl)ethyl] phosphate (TDCP).  No toxicity data on soil micro-organisms is available for 2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate].


 


Read-across


Read across from TDCP is considered justified on the grounds that:


- TDCP and 2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate] share similar soil adsorption properties (see section 5.4.1). The bioavailability of the substances is therefore expected to be comparable.


- Reliable toxicity data suggest a consistent low order of acute toxicity for 2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate] and TDCP to mico-organisms present in waste-water treatment plants (IC50 > 1000 mg/L, IC50 > 10000 mg/L resp, not further reported here)


- Reliable effects data are available for a range of other freshwater and terrestrial organisms for 2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate] and TDCP. In no instance does 2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate] cause an effects at a lower concentration than TDCP. Therefore it is not anticipated that read-across of this result could result in an overly favourable conclusionin respect of 2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate].


 


Toxicity to micro-organisms


In a 28 -day soil-microorganism nitrogen transformation test according to OECD 216 with TDCP a NOEC of ≥128 mg/kg soil (no inhibition at the highest concentration tested) was determined in the test. 


 


References:


- European Union Risk Assessment Report "2,2-Bis(chloromethyl)trimethylene bis[bis(2-chloroethyl)phophate]" (V6), CAS 38051-10-4, May 2008


- European Union Risk Assessment Reporttris[2-chloro-1-(chloromethyl)ethyl] phosphate” (TDCP), CAS 13674-87-8, May 2008