Registration Dossier
Registration Dossier
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EC number: 200-817-4 | CAS number: 74-87-3
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- NO DATA
- Author:
- Grant
- Year:
- 1 986
- Bibliographic source:
- Tox of the Eye, pg. 613
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Chloromethane
- EC Number:
- 200-817-4
- EC Name:
- Chloromethane
- Cas Number:
- 74-87-3
- Molecular formula:
- CH3Cl
- IUPAC Name:
- chloromethane
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Duration of treatment / exposure:
- ninety seconds
Results and discussion
In vivo
Results
- Irritation parameter:
- conjunctivae score
- Basis:
- other: two animals
- Time point:
- other: 90 seconds
- Score:
- 1
- Max. score:
- 1
- Irritant / corrosive response data:
- slight conjunctival hyperemia
Any other information on results incl. tables
Exposure of a rabbits eye to pure chloromethane gas at room temperature for ninety seconds caused only slight conjunctival hyperemia in two rabbits exposed for five days to concentrations from 250 to 465 ppm in air
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
