Octahydrocyclopenta[c]pyrrole

Short-term toxicity to fish

Administrative data

Endpoint:

short-term toxicity to fish

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

This study was performed following GLP requirements, but as a screening test and without analytical monitoring. Therefore, the test do not totally comply with the specific testing guideline but is well documented and scientifically acceptable. For this reason, we consider it as Klimish 2.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2010

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 203 (Fish, Acute Toxicity Test)

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

Octahydrocyclopenta[c]pyrrole

EC Number:

227-114-5

EC Name:

Octahydrocyclopenta[c]pyrrole

Cas Number:

5661-03-0

Molecular formula:

C7H13N

IUPAC Name:

octahydrocyclopenta[c]pyrrole

Test material form:

other: liquid

Details on test material:

Colourless liquid, stable, soluble in water, stored at room temperature.

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

yes

Details on test solutions:

On the dy of start of the study, a stock solution (nominal concentration : 1000 mg/L) in drinking water was prepared. the stock solution then was used to prepared solutions of the concentratins to be tested.

Test organisms

Test organisms (species):

Danio rerio (previous name: Brachydanio rerio)

Details on test organisms:

Danio Rerio Hamilton-Buchanan, sexually immature.
Length 2 +/-1cm.
The fishes were kept from 14 days under test conditions, before being used for the test. During this period, mortality didn't surpass 5%.

Study design

Test type:

static

Water media type:

freshwater

Total exposure duration:

96 h

Test conditions

Hardness:

1.18 mmol/L

Test temperature:

23 +/-2°C

pH:

8.23.

Dissolved oxygen:

8.9 mg/L.

Nominal and measured concentrations:

1-10-100 mg/L

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Duration:

96 h

Dose descriptor:

LC50

Effect conc.:

> 100 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality (fish)

Remarks on result:

other: 95% confidence interval not determinable

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Remarks:

except pH variation (1.6 unit instead of 1 unit max.)

Conclusions:

The result of the test is considered valid.
The 96h-NOEC = 100 mg/L and the 96h-LC50 > 100 mg/L.