Registration Dossier
Registration Dossier
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EC number: 407-000-3 | CAS number: 127519-17-9 CGL 384; TINUVIN 384
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 991
- Report date:
- 1991
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (Micronucleus)
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- A mixture of branched and linear C7-C9 alkyl 3-[3-(2H-benzotriazol-2-yl)-5-(1,1-dimethylethyl)-4-hydroxyphenyl]propionates
- EC Number:
- 407-000-3
- EC Name:
- A mixture of branched and linear C7-C9 alkyl 3-[3-(2H-benzotriazol-2-yl)-5-(1,1-dimethylethyl)-4-hydroxyphenyl]propionates
- Cas Number:
- 127519-17-9
- Molecular formula:
- C26H35N3O3~C28H39N3O3
- IUPAC Name:
- heptyl 3-[3-(2H-1,2,3-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl]propanoate; nonyl 3-[3-(2H-1,2,3-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl]propanoate; octyl 3-[3-(2H-1,2,3-benzotriazol-2-yl)-5-tert-butyl-4-hydroxyphenyl]propanoate
Constituent 1
Test animals
- Species:
- other: Mouse (Tif:Magf)
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- Arachis oil
- No. of animals per sex per dose:
- Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 16 hours
Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Male: 5000 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice time: 16 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice time: 24 hours
Female: 5000 mg/kg; No. of animals: 5; Sacrifice time: 48 hours
Results and discussion
Test results
- Sex:
- not specified
- Toxicity:
- yes
- Remarks:
- (Doses producing toxicity: P/N ratio - no apparent effect)
- Vehicle controls validity:
- not specified
- Negative controls validity:
- not specified
- Positive controls validity:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
None.
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