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EC number: 903-919-3 | CAS number: -
Test atmosphere concentrations
The test atmosphere concentration was sampled five times during the exposure. The actual concentration of the test item was calculated as the average of the concentrations obtained from gravimetry of the samples. The test item appeared as vapour, however, a small amount of aerosol was also detected in the cascade impactor. The aerosol particles presented approximately 0.04 % of the total mass of the test item in the test atmosphere.
Mean Achieved Concentration
Individual Body weight data:
Body weight (g)
Weekly Increase (g)
*Difference in %
Acute inhalation toxicity of test item reaction mass of 2,2'-oxybisbutane (DSBE), DIPE, SBA and 2-methylpropan-2-ol (TBA) was tested under GLP and according to OECD 403 and EU B.2 guidelines. A group of ten Wistar Crl:(WI) BR rats (five males and five females) was exposed to an atmosphere that contained the vapour and in small fraction (0.04 %) the aerosol of the test item. The animals were exposed for four hours using a nose-only exposure system, followed by a fourteen day observation period. The mean achieved atmosphere concentration was 21.0 +/- 2.21 mg/L.
In all male and female animals test item related clinical signs were found after removal from restraint on completion of the exposure. One hour after the exposure all animals slept.
All male and female animals were symptom-free from first day of observation period. The clinical signs represented the decreased activity and general reaction, tremor, incoordination and sleeping. On basis of body weight and body weight gain data, there was no notable test item effect observable in the exposed animals.
A single four hours nose-only exposure oftest item reaction mass of 2,2'-oxybisbutane (DSBE), DIPE, SBA and 2-methylpropan-2-ol (TBA) to CRL: (WI) BR rat followed by a 14-day observation period at a dose level 21.0 mg/L was not associated with any test item-related macroscopic findings on the male and female animals.
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