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EC number: 232-355-4
CAS number: 8007-24-7
Extractives and their physically modified derivatives. Anacardium occidentale, Anacardiaceae.
Table 1 Clinical observations, bodyweight and
mortality data - preliminary screening test - NX-4708
Concentration (% v/v) in acetone/olive oil 4:1
Bodyweight change (g) Day
In a dermal sensitization study with distilled CNSL in acetone/olive oil
4:1, four young adult CBA mice were tested using the LLNA method. Mild
redness to the eyes and neck were observed in test animals. No other
clinical signs of toxicity were noted and mortality did not occur. Body
weights of treated animals were comparable to that of controls.
Stimulation indexes of 29.29 and 30.90 were identified, for NX-4708 and
NX-2023, respectively. The EC3 value was not directly determined,
however, 10% of test substance elicited a stimulation index of 30 (EC3 =
% test substance required to elicit a stimulation index of 3). This
indicates that CNSL is a skin sensitiser category 1A.
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