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EC number: 608-929-9 | CAS number: 33955-44-1
An acute oral toxicity following OECD guideline 4223 and in compliance with GLP was performed to assess the test article's acute oral toxicity in Wistar rats. A single dose of 2000 mg/kg body weight of the test material preparation in 0.5 % Tylose CB 30.000 in Aqua bidest. was given to six fasted animals (three males and three females) by gavage in sequential manner. No mortality occurred. No signs of toxicity were observed in the male animals. Signs of toxicity noted in the 2,000 mg/kg dose group in the female animals comprised impaired and poor general state, dyspnoea, apathy, staggering, ataxia and piloerection. Findings were observed from 2 hours after application until including study day 3. The animals gained weight throughout the study period. No abnormalities were noted at necropsy of the animals at the end of the study. Under the conditions of this study the median lethal dose of the test substance after oral application was found to be greater than 2000 mg/kg body weight for the male and female animals.
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