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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
June 15, 1992-June 22, 1992
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Test procedure according to national standards.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: EEC Directives 83/467 and 84/449
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Reference substance name:
Benzene, mono-C10-14-alkyl derivs.
EC Number:
270-486-9
EC Name:
Benzene, mono-C10-14-alkyl derivs.
Cas Number:
68442-69-3
IUPAC Name:
dodecylbenzene
Test material form:
other: liquid
Details on test material:
No additional detail available

Test animals / tissue source

Species:
rabbit
Strain:
New Zealand White
Details on test animals or tissues and environmental conditions:
TEST ANIMALS
- Source: Conelli - Arona
- Weight at study initiation: 2.5-3.5 kg
- Housing: stainless steel cages
- Diet (e.g. ad libitum): pellet complete diet
- Water (e.g. ad libitum): filtered tap water, ad libitum

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 +/- 2 degree C
- Humidity (%): 55 +/- 15%
- Air changes (per hr): 25 changes/hr
- Photoperiod (hrs dark / hrs light): 12 hrs light/12 hrs dark


IN-LIFE DATES: From: June 15, 1992 To: June 22, 1992

Test system

Vehicle:
unchanged (no vehicle)
Controls:
other: untreated eye served as control
Amount / concentration applied:
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 ml
- Concentration (if solution): 100%
Duration of treatment / exposure:
7 days
Observation period (in vivo):
1, 24, 48, and 72 hrs, and 7 days after start of exposure
Number of animals or in vitro replicates:
6
Details on study design:
SCORING SYSTEM: Draize


Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: 24, 48, and 72 hrs
Score:
0
Max. score:
0
Reversibility:
fully reversible
Irritant / corrosive response data:
No signs of irritation or corrosion were seen in any animal during any of the observations.

Any other information on results incl. tables

Results of Eye Irritation Study  - Mean Scores                  

Observation

Cornea

Iris

Conjunctiva (Redness)

Conjunctiva (Chemosis)

1 hr

0

0

0

0

24 hrs

0

0

0

0

48 hrs

0

0

0

0

72 hrs

0

0

0

0

7 days

0

0

0

0

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The test substance is not an eye irritant according to EU GHS guidelines.
Executive summary:

In cases where no data were available on the target substance, Benzene, C15 -16 -alkyl derivs., data were read across from a structurally related material (the test substance).

This study examined the potential of the test substance to cause eye irritation. 0.1 ml of test substance was placed in one eye of 6 rabbits. The untreated eyes served as controls. The eyes were examined at 1, 24, 48, and 72 hrs, and 7 days after start of exposure for signs of irritation. No signs of irritation were seen in any animal at any observation. The test substance is considered no irritating to eyes.