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Administrative data

Description of key information

A secondary source indicates a lowest observed effect dose in the dose range for classification and labelling as harmful. The original report (Kodak 1971) was not available for review. The hazard category is consistent with that of the non-methylated analogue hydrquinone.
Secondary information indicates that the substance is less hazardous by the dermal route.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Information from RTECS database, limited information available (only species, exposure route and result), original study indicated to be reported in 1971.
Principles of method if other than guideline:
Rats were exposed to the test substance orally.
GLP compliance:
no
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
200 mg/kg bw
Endpoint conclusion
Endpoint conclusion:
adverse effect observed

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The Material Safety Datasheet by Eastman on this substance (Revision Date: 04/17/2002, MSDSUSAIANSIIENI150000001305/Version 3.0) states that the LD50 in rats is "200 - 400 mg/kg". Since Eastman aquired Kodak, it is expected that this MSDS actually represents the original value of the Kodak study. For mice, the LD50 is indicated to be greater than 400 mg/kg bw.It is therefore considered, that for the purposes of classification and labelling, the LD50 is greater than 300 mg/kg bw.

Justification for classification or non-classification