Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Review paper

Data source

Reference
Reference Type:
review article or handbook
Title:
Unnamed
Year:
1997
Report date:
2007

Materials and methods

Test guideline
Guideline:
other: No data
Deviations:
not specified
Principles of method if other than guideline:
No data
GLP compliance:
not specified
Test type:
other: No data

Test material

Constituent 1
Chemical structure
Reference substance name:
2-propylvaleric acid
EC Number:
202-777-3
EC Name:
2-propylvaleric acid
Cas Number:
99-66-1
Molecular formula:
C8H16O2
IUPAC Name:
2-propylpentanoic acid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Doses:
No data
No. of animals per sex per dose:
No data
Control animals:
not specified
Statistics:
No data

Results and discussion

Preliminary study:
No data
Effect levels
Dose descriptor:
LD50
Effect level:
ca. 670 mg/kg bw
Mortality:
No data
Clinical signs:
other: No data
Gross pathology:
No data

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Valproic acid has a reported LD50 (oral rat) of 670mg/kg