Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

There are multiple reliable studies with losartan potassium on mutagenicity, including in vitro and in vivo, all of which have a negative result. Therefore, it can be concluded by read-across that losartan free acid is also non-genotoxic.

Justification for selection of genetic toxicity endpoint
in vivo study

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

The analogue substance, and therefore also losartan free acid, does not meet the criteria for classification as a mutagen according to DSD or CLP regulations.