Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 601-329-8 | CAS number: 114798-26-4
Distribution modelling
Administrative data
- Endpoint:
- distribution modelling
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Modelling
- Title:
- Fugacity
- Author:
- EPISUITE v4.1
- Year:
- 2 013
- Bibliographic source:
- US EPA. 2013. Estimation Programs Interface Suite™ for Microsoft® Windows, v 4.1.1. United States Environmental Protection Agency, Washington, DC, USA.
Materials and methods
Test material
- Reference substance name:
- [2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazol-5-yl]methanol
- EC Number:
- 601-329-8
- Cas Number:
- 114798-26-4
- Molecular formula:
- C22H23ClN6O
- IUPAC Name:
- [2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazol-5-yl]methanol
- Details on test material:
- Level III Fugacity Model (Full-Output):
=======================================
Chem Name : Losartan free acid
Molecular Wt: 422.92
Henry's LC : 1.28e-006 atm-m3/mole (calc VP/Wsol)
Vapor Press : 1.1e-005 mm Hg (user-entered)
Log Kow : 1.1 (user-entered)
Soil Koc : 1.41e+005 (KOCWIN MCI method)
Constituent 1
Results and discussion
Percent distribution in media
- Air (%):
- 0.113
- Water (%):
- 6.86
- Soil (%):
- 45.6
- Sediment (%):
- 47.5
Any other information on results incl. tables
Level III Fugacity Model (Full-Output):
=======================================
Chem Name : Losartan free acid
Molecular Wt: 422.92
Henry's LC : 1.28e-006 atm-m3/mole (calc VP/Wsol)
Vapor Press : 1.1e-005 mm Hg (user-entered)
Log Kow : 1.1 (user-entered)
Soil Koc : 1.41e+005 (KOCWIN MCI method)
Mass Amount Half-Life Emissions
(percent) (hr) (kg/hr)
Air 0.113 5.04 1000
Water 6.86 900 1000
Soil 45.6 1.8e+003 1000
Sediment 47.5 8.1e+003 0
Fugacity Reaction Advection Reaction Advection
(atm) (kg/hr) (kg/hr) (percent) (percent)
Air 3.52e-012 908 66 30.3 2.2
Water 4.99e-012 308 401 10.3 13.4
Soil 1.32e-013 1.02e+003 0 34.2 0
Sediment 6.2e-012 237 55.5 7.91 1.85
Persistence Time: 1.95e+003 hr
Reaction Time: 2.36e+003 hr
Advection Time: 1.12e+004 hr
Percent Reacted: 82.6
Percent Advected: 17.4
Half-Lives (hr), (based upon Biowin (Ultimate) and Aopwin):
Air: 5.04
Water: 900
Soil: 1800
Sediment: 8100
Biowin estimate: 2.441 (weeks-months)
Advection Times (hr):
Air: 100
Water: 1000
Sediment: 5e+004
Applicant's summary and conclusion
- Executive summary:
The estimated environmental distribution endpoint summary is included for use in the exposure modelling in the Chesar tool.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
