Registration Dossier

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: RELIABLE SUMMARY REPORT.
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
review article or handbook
Title:
IUCLID DATASET SUBSTANCE ID:68512-62-9
Author:
EUROPEAN COMMISSION - EUROPEAN CHEMICALS BUREAU
Year:
2000
Bibliographic source:
IUCLID DATASET SUBSTANCE ID:68512-62-9 PG 35

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: DRAIZE TEST
Deviations:
not specified
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
not specified
Preparation of test site:
other: ABRADED AND NOT ABRADED
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
24h
Observation period:
14 days
Number of animals:
6

Results and discussion

In vivo

Results
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 0.2
Max. score:
8
Reversibility:
no data

Any other information on results incl. tables

A mean primary dermal irritation index of 0.2 out of a maximum score of 8.0 indicated that the test substance was minimally irritating.

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
minimally irritating