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EC number: 610-545-1
CAS number: 50588-42-6
There are no available genetic toxicity
studies on didenac. Results of a study conducted with a structurally
similar compound (dienone) are reported and used for read across.
Dienone was evaluated in a bacterial
mutagenicity assay over a range of concentrations using four strains of
Salmonella typhimurium (TA1535, TA1537, TA98 and TA100) and two strains
of Eschericia coli (WP2P and WP2P uvrA) in the presence and absence of a
rat liver-derived metabolic activation system (S9-mix).
In two separate experiments, the test
substance did not induce any significant, reproducible increases in the
observed numbers of revertant colonies in any of the tester strains
used, either in the presence or absence of S9-mix.
The sensitivity of the test system, and the
metabolic activity of the S9-mix, were clearly demonstrated by the
increases in the numbers of revertant colonies induced by positive
It is concluded that, under the conditions
of this assay, Dienone gave a negative, ie non-mutagenic response in S.
typhimurium strains TA1535, TA1537, TA98, and TA100 and E.coli strains
WP2P and WP2P uvrA in both the presence and absence of S9-mix.
By read across, didenac gives a negative,
non-mutagenic response under the conditions of the test.
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