Registration Dossier
Registration Dossier
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EC number: 203-526-0 | CAS number: 107-85-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Mutagenicity in bacteria
Isopentylamine was tested for its potential to induce mutations in bacteria in vitro with and without metabolic activation according to OECD TG 471 and under GLP conditions. The test strains included S. typhimurium TA1535, TA1537, TA98, TA100, and E. coli WP2 uvr A. The test concentrations were 0; 20; 100; 500; 2500 and 5000 µg/plate (with and without S9-mix) in the standard plate test. Concentrations in preincubation tests were 0; 4; 20; 100; 500 and 2500 µg/plate (with and without S9-mix) in the first and 0, 0.4, 2, 10, 50 and 150 µg/plate (without metabolic activation) in the second preincubation test.
Isopentylamine was not mutagenic in any strain. No precipitation was noted. Cytotoxicity was seen from 2500 µg/plate onwards in the standard plate test, and from 20 µg/plate onwards in the preincubation tests. Negative and positive controls performed as expected. This test is considered to be valid for assessment, and it is concluded that isopentylamine is not mutagenic in bacteria (BASF, 1999).
Short description of key information:
Isopentylamine was not muatgenic in bacteria, with and without metabolic activation.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
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