Isopentylamine

Specific investigations: other studies

Administrative data

Endpoint:

specific investigations: other studies

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Study period:

01-01-1992

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well-documented publication/study report which meets basic scientific principles. Read across of results obtained with other short-chain (C3-C8) from n/i-aliphatic amines.

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1993

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

The respiratory irritation was examined in mice during the first 15 minutes of the inhalation exposure at several concentrations in the air with and without tracheal cannulation. The maximum respiratory depression was compared with the breathing rate before the inhalation exposure.

GLP compliance:

not specified

Type of method:

in vivo

Endpoint addressed:

respiratory irritation

Test material

Test material information

Constituent 1

Reference substance name:

Pentylamine

EC Number:

203-780-2

EC Name:

Pentylamine

Cas Number:

110-58-7

IUPAC Name:

pentan-1-amine

Constituent 2

Reference substance name:

n-Pentylamine

IUPAC Name:

n-Pentylamine

Test animals

Species:

mouse

Strain:

CF-1

Sex:

male

Administration / exposure

Route of administration:

inhalation: vapour

Vehicle:

air

Details on exposure:

INHALATION

Method: head only
Exposure duration: 60 minutes
Inhalation concentration: 17-300 ppm, depending on test substance
Number of exposure concentrations: 4-6 per test substance
Number of animals: 6 previously unexposed mice at each level

Analytical verification of doses or concentrations:

yes

Details on analytical verification of doses or concentrations:

Sampling on silica gel, desorption and derivation to the m-toluol derivatives. Analyses: HPLC/UV detection on reverse phase column,

Duration of treatment / exposure:

60 minutes

Frequency of treatment:

1

Doses / concentrations

Remarks:

Doses / Concentrations:
n-pentylamin: 25, 50, 100, 200 ppm
Basis:
analytical conc.

No. of animals per sex per dose:

6

Control animals:

other: not required

Examinations

Examinations:

Breathing frequency 15 min before expsoure, and 15 min after start of exposure.

Applicant's summary and conclusion

Conclusions:

Primary aliphatic amines including n- and i-pentylamine cause respiratory irritation due to irritation of the upper airways

Executive summary:

Primary aliphatic amines including n- andi-pentylamine cause respiratory irritation due to irritation of the upper airways. The RD₅₀values of the examined saturated n- and iso-amines with chain lengths of C3 to C8 decrease with increasing chain length. A linear relationship was obtained in a plot of Log RD₅₀versus Log P. The RD₅₀of n-pentylamine was 64 ppm (Gagnaire et al. 1993).

 

The RD₅₀values of n- andiso-amines were very similar. It is therefore concluded that the RD₅₀value of isopentylamine is in the range of 60 -70 ppm.