Registration Dossier
Registration Dossier
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EC number: 939-722-4 | CAS number: -
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Irritation was evaluated as part of phototoxicity study, in which 15 non-haired mice (hairless:hrhr) were given a single dermal application of the undiluted test material (20 ul) on an area of skin measuring approximately 5-cm2. Treated skin that was not exposed to the light was evaluated for irritation. The positive control was a 0.01% solution of 8-methoxypsoralen (8-MOP) in methanol, and the negative control was the vehicle (methanol) alone. If dilutions were necessary, the test material was diluted in methanol.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Cornmint oil
- IUPAC Name:
- Cornmint oil
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Hairless hrhr
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: Hairless mice
- Vehicle:
- other: Methanol
- Number of animals:
- 15 mice
Results and discussion
In vivo
- Irritant / corrosive response data:
- No irritant effect observed.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: not specified
- Conclusions:
- Cornmint oil did not shown any irritant effect. Thus, it is not considered as an irritating substance for skin.
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