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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
An oral LD50 study was conducted in which 10 rats received 5 g/kg dose of the test material. The animals were observed for mortality and/or systemic effects for 14 days.
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
Cornmint oil
IUPAC Name:
Cornmint oil
Test material form:
not specified

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Doses:
Rats received 0.5 g/kg to 5 g/kg dose of the test material
No. of animals per sex per dose:
10 rats per dose
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 1 240 mg/kg bw
Based on:
not specified
Mortality:
Dose
0.5 g/kg => 1/10 immediate death (within 24 hours)
1.2 g/kg => 5/10 immediate death (within 24 hours)
1.6 g/kg => 6/10 immediate death (within 24 hours)
5 g/kg => 10/10 immediate death (within 24 hours)

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The acute oral LD50 in rats is 1.24 g/kg or 1240 mg/kg bodyweight.
According to the CLP regulation, the DL50 triggers a classification as acutely toxic, oral, category 4.