Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Reference:
Composition 0
Principles of method if other than guideline:
Method not published
GLP compliance:
not specified
Limit test:
no
Test material information:
Composition 1
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
256 mg/kg bw
Based on:
not specified
Interpretation of results:
toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The Oral LD50 value in rat of the substance is reported to be 256 mg/kg bw . 3 -Chloroaniline is therefore classified Toxic if swallowed.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
256 mg/kg bw
Quality of whole database:
Test method not reported.

Acute toxicity: via inhalation route

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Reference
Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Reference:
Composition 0
Principles of method if other than guideline:
Method not published
GLP compliance:
not specified
Test material information:
Composition 1
Species:
mouse
Strain:
not specified
Sex:
not specified
Route of administration:
inhalation
Type of inhalation exposure:
not specified
Vehicle:
not specified
Duration of exposure:
4 h
Sex:
not specified
Dose descriptor:
LC50
Effect level:
550 mg/m³ air
Based on:
not specified
Exp. duration:
4 h

Lungs, thorax or respiration: cyanosis

Vehavioral: convulsions or effect on sezure threshold

Sense organs and special senses (eye): corneal damage

Interpretation of results:
Toxicity Category III
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The LD50 value for inhalation route in mouse of the substance is reported to be 550 mg/m^3 (0.55 mg/l) .
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LC50
550 mg/m³
Quality of whole database:
Test method not reported.

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Reference:
Composition 0
Principles of method if other than guideline:
Method not published
GLP compliance:
not specified
Limit test:
no
Test material information:
Composition 1
Species:
rat
Strain:
not specified
Sex:
not specified
Type of coverage:
not specified
Vehicle:
not specified
Sex:
not specified
Dose descriptor:
LD50
Effect level:
250 mg/kg bw
Based on:
not specified
Interpretation of results:
toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
The dermal LD50 value in rat of the substance is reported to be 250 mg/kg . 3-Chloroaniline is therefore classified Toxic in contact with skin.
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
250 mg/kg bw
Quality of whole database:
Test method not reported.

Additional information

Justification for selection of acute toxicity – oral endpoint
The preferred test species for evaluation of acute toxicity by the oral route is the rat.

Justification for selection of acute toxicity – inhalation endpoint
More accurate data

Justification for selection of acute toxicity – dermal endpoint
The preferred test species for evaluation of acute dermal toxicity is the rat or the rabbit.

Justification for classification or non-classification

On the basis of the available data 3-Chloroaniline is classified Toxic if swallowed, in contact with skin and if inhaled.

The Chloroanilines have a CLP harmonized classification (Annex VI, Table 3.1, Index no.612-010-00-8).