Registration Dossier
Registration Dossier
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EC number: 701-248-9 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Short-term toxicity to aquatic invertebrates of the substance is derived using read across. EC 500-029-3 was determined to result in a 3 hour EC2 > 720 mg/L, EC 500-044-5 in a 3 hour-EC10 > 10,000 mg/L and EC500-118-7 in a 3 hour-NOEC >= 10,000 mg/L. Overall it can be assumed that all three read across substances give a 3 hour-NOEC >= 10,000 mg/L.
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 10 000 mg/L
Additional information
In a read across approach studies of three read across substances were used to describe toxicity to microorganisms of the substance.
Hypothesis for the read-across approach:
Group: Reaction mass of Glycerol, propoxylated and Sucrose, propoxylated;Succhrose, propoxylated; Propylidynetrimethanol, propoxylated; Glycerol, propoxylated; D‑Glucitol, propoxylated; Propane-1,2-diol, propoxylated; Pentaerythritol, propoxylated; 2,2',2''‑Nitrilotriethanol, propoxylated; Trimethylolpropane, ethoxylated; Diethylene glycol, propoxylated; Ethylene glycol, propoxylated; Diethanolamine, propoxylated.
The substance is member of a group of chemicals with similar chemical structure and physical behaviour:
1.) Chemical similarity: All of these substances have terminal OH-groups and ether-linkages as common structural features. Thus, the substances differ from each other only in the identity/type of starter molecule (aliphatic alcohols with 2 to 8 hydroxy functions) used and its associated bonding with the alkoxylate repeating units. Typically the products are substances with a range of Ethyleneoxide or Propyleneoxide units (1 -12.5) added to starter molecules. All substances are characterised by a molecular weight distribution of ca. 150 - 1000. The common function of the members of the group is to allocate a high number of hydroxy functions which are intended to react with e.g. an isocyanate.
2.) Physical behaviour: All members of the group are liquids with elevated viscosity, high solubility in water (> 100 g/L) and a low vapour pressure (<0.0003 hPa).Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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