Registration Dossier
Registration Dossier
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EC number: 408-050-9 | CAS number: 76855-69-1 4-AA; AOSA; AZETIDONE-KANEKA; GR91990X
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V, B.3
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- (2R,3R)-3-((R)-1-(tert-butyldimethylsiloxy)ethyl)-4-oxoazetidin-2-yl acetate
- EC Number:
- 408-050-9
- EC Name:
- (2R,3R)-3-((R)-1-(tert-butyldimethylsiloxy)ethyl)-4-oxoazetidin-2-yl acetate
- Cas Number:
- 76855-69-1
- Molecular formula:
- C13H25NO4Si
- IUPAC Name:
- (2R,3R)-3-[(1R)-1-[(tert-butyldimethylsilyl)oxy]ethyl]-4-oxoazetidin-2-yl acetate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- not specified
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 000 mg/kg bw
- Mortality:
- no mortality
- Clinical signs:
- other: No significant signs of systemic toxicity.
- Gross pathology:
- None
- Other findings:
- Slight skin irritation (desquamation, erythema, oedema, scabbing) in all animals. Complete recovery by day 10.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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