Registration Dossier
Registration Dossier
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EC number: 201-159-0 | CAS number: 78-93-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Acute oral toxicity:
According to the data provided in the REACH dossier of butanone, dissiminated on the ECHA homepage, butanone is considered to be of low toxicity after single ingestion.
Rat oral: LD50 = 4.29 ml/kg bw
Rat oral: LD50 = 2193 mg/kg bw (read across secondary butyl alcohol).
Further data from secondary sources (MAK documentation of the Deutsche Forschungsgemeinschaft-DFG); OECD SIDS) reported oral LD50 values in mice and rats between 2000 and 6000 mg/kg bw.
Acute inhalation toxicity:
In an inhalation hazard test Sprague Dawley rats were exposed to an atmosphere that had been saturated with the volatile parts of butanone (vapour) at 20°C (BASF 1980). Nominal test substance concentrations ranged between 220 and 330 mg/l (not verified analytically). After 10 minutes exposure 0/12 animals died. Mortality was observed after 30 minutes, 1 hour and 1.2 hour exposure (2/18, 1/6, 3/6 animals respectively). Evidences for irritative effects on the respiratory system and narcotic effects have been observed.
Data from secondary source (OECD SIDS) reported inhalation LC50 values in rats to be greater than 5000 ppm (>15 mg/l). Overall butanone is considered to be of low toxicity after acute inhalation.
Acute dermal toxicity:
According to the data provided in the REACH dossier of butanone, dissiminated on the ECHA homepage, butanone is considered to be virtually non toxic after single skin contact.
Rabbit dermal: LD50 > 10 ml/kg bw
Further data from secondary source (OECD SIDS) reported dermal LD50 values in rabbits from 6.4 to 8 g/kg bw.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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