Registration Dossier
Registration Dossier
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EC number: 201-159-0 | CAS number: 78-93-3
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- publication
- Title:
- Detoxification of specific organic substances by wet oxidation
- Author:
- Randall T.L. & Knopp P.V.
- Year:
- 1 980
- Bibliographic source:
- Journal Water Pollution Control Federation 52(8): 2117-2130
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EPA-660/3-75-009 (1975): "method for acute toxicity tests with fish, macroinvertebrates, and amphibians"
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Butanone
- EC Number:
- 201-159-0
- EC Name:
- Butanone
- Cas Number:
- 78-93-3
- Molecular formula:
- C4H8O
- IUPAC Name:
- butan-2-one
- Details on test material:
- - Name of test material (as cited in study report): 2-butanane (MEK)
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Age at study initiation (mean and range, SD): first instar larvae (age 12 +- 12 h)
Cultured according to the method of Beisinger.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 154.5 (89.5 - 180) mg/l as CaCO3
- Test temperature:
- 22 °C
- pH:
- 7.7 (7.0 - 8.2)
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 5 091 mg/L
- Remarks on result:
- other: 95% CL: 4025-6440 mg/L
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
