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EC number: 800-426-4 | CAS number: 1373883-45-4
EL50 (48h) > 1000 mg/L (OECD 202, Daphnia magna); read-across
Since no studies investigating the short-term toxicity to aquatic invertebrates of Fatty acids, C18 unsaturated, trimers, hydrogenated are available, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5, a read across to the structurally similar substances Fatty acids, C18-unsatd., trimers (CAS No. 68937-90-6) and Fatty acids, C16-18 and C18-unsatd., branched and linear (CAS No. 68955-98-6) was conducted. Further justification is given within the endpoint summary 6.1 and within the analogue justification in Section 13.
The key study conducted with Fatty acids, C18-unsatd., trimers (CAS No. 68937-90-6) was performed according to ISO 14669 and GLP (Källqvist, 2004). The marine test organism Acartia tonsa was exposed to the test substance in a static system at loading rates of 100, 180, 320, 560 and 1000 mg/L for 48 hours. Due to the poor solubility of the test material, the test solutions were prepared as water accommodated fractions (WAF). The mortality was less than 5% at WAF loadings up to 1000 mg/L, and the LL50 was determined to be ≥ 1000 mg/L.
The key study conducted with Fatty acids, C16-18 and C18-unsatd., branched and linear (CAS No. 68955-98-6) was performed according to OECD Guideline 202 (Sewell, 1994). The test organism Daphnia magna was exposed to the test substance in a static system at a loading rate of 1000 mg/L, prepared as water accommodated fractions (WAF), for 48 hours. As no effects were observed during the study, the EL50 was determined to be > 1000 mg/L.
Thus, based on the above mentioned result, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no short-term toxicological effects on aquatic invertebrates are expected up to the limit of water solubility (0.001 mg/L) for Fatty acids, C18 unsaturated, trimers, hydrogenated.
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