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EC number: 942-135-6 | CAS number: -
Skin Irritation/CorrosionThe key study for skin irritation/corrosion was a reliable (Klimisch 1) OECD 404 study with docosan-1-ol. In this study docosan-1-ol was considered not to be a skin irritant when applied to rabbit skin.Eye IrritationThe key study for eye irritation was a reliable (Klimisch 1) OECD 405 study with docosan-1-ol. In this study docosan-1-ol was considered not to be an eye irritant.
Alcohols, C20-30 (even numbered), is a UVCB substance that comprises several linear long chain alcohols, predominantly tetracosan-1-ol (C24), hexacosan-1-ol (C26), and octacosan-1-ol (C28). Together, these substances make up approximately 70% of the composition of Alcohols, C20-30 (even numbered). Other constituents include, to a much lesser extent, secondary long chain alcohols and complex mixtures of long chain carboxylate esters. On this basis, study data, where available, for each of the long chain alcohol constituents has been evaluated and considered together; this is consistent with the Category approach applied for Long Chain Alcohols (LCA) under REACH. In a conservative approach the most sensitive study result from the constituents of the LCA category have been identified and used to address the endpoint in question
A reliable (Klimisch 1) OECD 404 study was conducted with docosan-1-ol. Rabbits were treated with undiluted docosan-1-ol in a 4 hour semi-occlusive exposure. No evidence of skin irritation was noted during the study other than very slight erythema at one test site at 1 hour after patch removal. All other scores were 0. Docoson-1-ol was considered not irritating to rabbit skin. Consequently in line with the read-across justification included, Alcohols, C20-30 (even numbered), is considered to be non-irritating.
A reliable (Klimisch 1) OECD 405 was conducted with docosan-1-ol. Moderate conjunctival irritation was reported in all animals one hour after treatment with minimal to moderate conjunctival irritation at the 24 hour observation time. At 48 hours minimal conjunctival redness was observed in one animal only. All scores were 0 at 72 hours. Docoson-1-ol was considered not irritating to the rabbit eye. Consequently in line with the read-across justification included, Alcohols, C20-30 (even numbered), is considered to be non-irritating to eyes.
These findings do not warrant the classification of Alcohols, C20-30 (even numbered), as skin or ocular irritants under the new Regulation (EC) 1272/2008 on classification, labelling and packaging of substances and mixtures (CLP) and under the Directive 67/518/EEC for dangerous substances and Directive 1999/45/EC for preparations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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