Registration Dossier
Registration Dossier
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EC number: 942-135-6 | CAS number: -
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific principles, acceptable for assessment. Study considered valid although result reporting is limited.
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-finding toxicity data: List VII.
- Author:
- Smyth H F, Carpenter C P, Weil C S, Pozzani U C, Striegel J A, Nycum J S
- Year:
- 1 969
- Bibliographic source:
- Am. Ind. Hyg. Assoc. J. 30(5): 470-476
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Method: other: Smyth et al, 1962
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Icosanol - mixed isomers
- IUPAC Name:
- Icosanol - mixed isomers
- Details on test material:
- icosanol (mixed isomers)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- - Source: no data
- Weight at study initiation: 2.5 -3.5 kg
- Group size: 4
- Controls: no
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- - Area covered: entire trunk
- No. of animals per sex per dose:
- 4
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 20 mL/kg bw
Any other information on results incl. tables
Results were not reported in detail. The LD50 was >20 ml/kg. (>16,800 mg/kg using the density of 0.84 g/cm3 reported in chapter 2.3). No further
details available.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- An LD50 value of >20ml/kg is reported in a study which even though lacking in detail is deemed reliable and equivalent to guideline.
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