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EC number: 687-349-8 | CAS number: 173194-95-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study conducted following OECD and EU methods and under GLP conditions..
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- (6-hydroxynaphthalen-2-yl)boronic acid
- EC Number:
- 687-349-8
- Cas Number:
- 173194-95-1
- Molecular formula:
- C10H9BO3
- IUPAC Name:
- (6-hydroxynaphthalen-2-yl)boronic acid
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Substance type: off white powder
- Physical state: solid
- Storage condition of test material: room temperatire until 14 October 2013 and then approximately 4° C in the dark
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Harlan Laboratories UK
- Age at study initiation: 12 - 20 weeks old
- Weight at study initiation: 2.52 to 2.74kg
- Housing: Suspended Cages
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: approximately 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 17-23
- Humidity (%): 30-70
- Air changes (per hr): at least 15
- Photoperiod: 12 hrs dark / 12 hrs light
Test system
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: volume of 0.1ml, weight approx 48mg - Duration of treatment / exposure:
- The test material was administered via syringe into the conjunctival sac of the right eye. The upper and lower eyelids were held together for about one second immediately after treament, to prevent loss of the test item, then released.
- Observation period (in vivo):
- The 3 rabbits were assessed immediately for pain reaction and assessment of ocular damage/irritation was made approximately 1 hour, 12, 24 and
72 hours following treatement. - Number of animals or in vitro replicates:
- 3 rabbits
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
Test substance could not be removed as was injected into the conjunctival sac of the right eye
SCORING SYSTEM:
The Draize scale was used. The numerical values corresponding to each animal, tissue and observation time were recorded. The data relating to the conjunctivae were designated by the letters A (redness), B (chemosis) and C (discharge), those relating to the iris designated by the letter D and those relating to the
cornea by the letters E (degree of opacity) and F (area of cornea involved). For each tissue the score was calculated as follows:
Score for conjunctivae (A + B + C) x 2
Score for iris D x 5
Score for cornea (E x F) x 5
TOOL USED TO ASSESS SCORE: opthalmoscope
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 1 hour
- Score:
- 15.3
- Max. score:
- 17
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 10.7
- Max. score:
- 12
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 6
- Max. score:
- 8
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 2.7
- Max. score:
- 8
- Reversibility:
- fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 7 days
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible within: 7 days
- Irritant / corrosive response data:
- Individual and group mean scores for ocular irritation are given in Table 1 (attached below) and Table 2 (attached below).
No corneal effects were noted during the study.
Iridial inflammation was noted in two treated eyes one hour after treatment.
Moderate conjunctival irritation was noted in all treated eyes one and 24 hours after treatment. Moderate conjunctival irritation was noted in one treated eye and minimal conjunctival irritation was noted in two treated eyes at the 48-Hour observation. Minimal conjunctival irritation was noted in two treated eyes at the 72-Hour observation.
One treated eye appeared normal at the 72-Hour observation and two treated eyes appeared normal at the 7-Day observation.
The test item produced a maximum group mean score of 15 .3 and was classified as a moderate irritant (Class 5 on a 1 to 8 scale) to the rabbit eye
according to a modified Kay and Calandra classification system. - Other effects:
- Individual body weights and body weight change are given in Table 3 (attached below)
All animals showed expected gain in body weight during the study
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test item produced a maximum group mean score of 15 .3 and was classified as a moderate irritant (Class 5 on a 1 to 8 scale) to the rabbit
eye according to a modified Kay and Calandra classification system.
The test item does not meet the criteria for classification according to the Globally Harmonized System of Classification and Labelling of Chemicals or Regulation (EC) No 1272/2008, relating to the Classification, Labelling and Packaging of Substances and Mixtures. - Executive summary:
The study was performed to assess the irritancy potential of the test item to the eye of the New Zealand White rabbit.
A single application of the test item (Boronic Acid) to the non-irrigate eye of three rabbits produced iridial inflammation and moderate conjunctival irritation. Once treated eye appreared normal at the 72 hour observation and two treated eyes appeared normal at the 7 day observation.
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