Registration Dossier
Registration Dossier
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EC number: 251-529-0 | CAS number: 33456-68-7
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolyl)ethyl]benzenesulphonamide
- EC Number:
- 251-529-0
- EC Name:
- p-[2-(3,4-dihydro-7-methoxy-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolyl)ethyl]benzenesulphonamide
- Cas Number:
- 33456-68-7
- Molecular formula:
- C20H22N2O5S
- IUPAC Name:
- 4-[2-(7-methoxy-4,4-dimethyl-1,3-dioxo-1,2,3,4-tetrahydroisoquinolin-2-yl)ethyl]benzene-1-sulfonamide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): AR-FD 26 ( phase X )
- Physical state: powder
- Lot/batch No.: 01010
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not specified
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- For each test and controls has been used 20 Daphnias magna, divided into four
groups of five animals.
Study design
- Test type:
- not specified
- Water media type:
- not specified
- Total exposure duration:
- 48 h
Test conditions
- Hardness:
- 167.94 mg/L
- Test temperature:
- 18° a 22° ±1 °C
- pH:
- 7.0
- Dissolved oxygen:
- not upper 60 %
- Nominal and measured concentrations:
- Primephase tested dose: Blank, 0.1% and 0.01%.
Second phase tested dose: Blank, 0.01% and 0.001% - Details on test conditions:
- - Not feeding
- Lighting: 16 hours - Reference substance (positive control):
- not specified
- Remarks:
- In "Daphnia magna" has made dichromate test
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 400 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The 48h-EC50 of AR-DF 26 (Phase X) was 400 mg/L .
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