Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 October 2015 - 24 December 2015
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2016

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 420 (Acute Oral Toxicity - Fixed Dose Method)
GLP compliance:
yes (incl. QA statement)
Test type:
fixed dose procedure
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(4-chloro-2-fluorophenyl)acetonitrile
EC Number:
642-783-7
Cas Number:
75279-53-7
Molecular formula:
C8 H5 Cl F N
IUPAC Name:
2-(4-chloro-2-fluorophenyl)acetonitrile
Test material form:
other: white solid
Details on test material:
Roche number : RO0401413-000
Formula : C8H5ClFN
Molecular weight : 169,6 g/mol
Batch : 280001T01O
Purity : 100 % (m/m)
Expiry date : 31 December 2015
Storage conditions : room temperature in the dark under nitrogen

Test animals

Species:
rat
Strain:
Wistar
Sex:
female

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
arachis oil
Doses:
2000 mg/kg and 300 mg/kg
No. of animals per sex per dose:
1 female rat at 2000 mg/kg
5 female rats at 300 mg/kg
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
>= 300 - <= 2 000 mg/kg bw
Based on:
test mat.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Executive summary:

The acute oral median lethal dose (LD50) of PAC-Nitrile in the female Wistar strain rat was estimated to be in the range of 300 -2000 mg/kg body weight