Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 258-799-9 | CAS number: 53817-09-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976-04-28 to 1977-06-07
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- 4-amino-N-(2-ethylhexyl)benzenesulphonamide
- EC Number:
- 258-799-9
- EC Name:
- 4-amino-N-(2-ethylhexyl)benzenesulphonamide
- Cas Number:
- 53817-09-7
- Molecular formula:
- C14H24N2O2S
- IUPAC Name:
- 4-amino-N-(2-ethylhexyl)benzene-1-sulfonamide
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Gaukler
- Weight at study initiation: animal #1 2.99 kg, animal #2 2.82 kg
- Diet: Ssniff
IN-LIFE DATES: From: 1976-03-24 To: 1976-04-01
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: other eye of test animal treated was with talcum powder
- Amount / concentration applied:
- about 50 mm3, i.e. ca. 50 mg
- Observation period (in vivo):
- 8 days
- Number of animals or in vitro replicates:
- 2
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing: The test substance was not washed out
SCORING SYSTEM: observed were the parameters redness and chemosis of conjunctivae, and corneal opacity
Grading system for redness and edema: The data reported have to be converted into presently used numerical grading system as given in the following table
"reizlos" (no symptom) Ø, "fraglich" (questionable) (+): considered as equivalent to grade 0 (no irritating effect) according to OECD Draize scheme
"leicht" (slight) +: considered as equivalent to grade 1 (very slight effect) according to OECD Draize scheme
"stark" (marked) ++: considered as equivalent to grade 2 (well-defined effect) effect according to OECD Draize scheme
"sehr stark" (severe) +++: considered as equivalent to grade ≥3 (severe effect) according to OECD Draize scheme
Grading system for iritis: iritis + or ++ equals Draize scheme grade 1 or 2, respectively.
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- other: 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: in addition a "smeary layer" was reported at 24 h
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- other: 24 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Irritant / corrosive response data:
- Test item treatment: Slight conjunctival redness was observed at both test animals after 1 h and after 24 h; effects observed to be fully reversible after 8 d.
Control eye treatment with talcum: Control eye of both animals showed slight conjunctival redness after 1 h and after 24 h such as the eye treated with test item; effects also observed to be fully reversible after 8 d. Both control eyes furthermore showed edema after 1 h, grade 3 for animal #1 and grade 2 for animal #2.
Any other information on results incl. tables
Table of results based on grading system as applied in the study report
time |
animal 1 |
animal 2 |
|
conjunctivae |
1 h |
+ |
+ |
24 h |
+ |
+ |
|
8 d |
Ø |
Ø |
|
chemosis |
1 h |
Ø |
Ø |
24 h |
Ø |
Ø |
|
8 d |
Ø |
Ø |
|
cornea |
1 h |
Ø |
Ø |
24 h |
Ø |
Ø |
|
8 d |
Ø |
Ø |
Table of results based on grading system as applied by the Draize scheme
time |
animal 1 |
animal 2 |
|
conjunctivae |
1 h |
1 |
1 |
24 h |
1 |
1 |
|
8 d |
0 |
0 |
|
chemosis |
1 h |
0 |
0 |
24 h |
0 |
0 |
|
8 d |
0 |
0 |
|
cornea |
1 h |
0 |
0 |
24 h |
0 |
0 |
|
8 d |
0 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.