Registration Dossier

Administrative data

First-aid measures

General information: As a general rule, in case of doubt or if symptoms persist, always call a doctor.Never give anything by mouth to an unconscious person. If unconscious, placein recovery position and seek medical advice.
In case of inhalation: Remove victim to fresh air and keep at rest in a position comfortable and well-ventilated for breathing. In case of irritation of respiratory system or mucous membranes and/or indisposition and/or prolonged exposure, seek medical attention.
In case of skin contact: Flush skin with plenty of mild soap and water for at least 15 minutes while removing contaminated clothing and shoes. Do not use organic solvents. If sticky, use waterless cleaner first. Get medical aid if irritation develops or persists. Wash contaminated clothing before reusing.
In case of eye contact: Check for and remove any contact lenses. Immediately flush eyes with runningclean water for at least 15 minutes, keeping eyelids open. Obtain emergency medical attention (e.g. contact ophthalmologist) if pain, blinking, tears or redness persist.
In case of ingestion: Immediately give plenty (> 500 ml) of water (if possible charcol slurry). In case of spontaneous vomiting be sure that vomitus can freely drain due of danger of suffocation. Give water repeatedly. Do not induce vomiting/risk of damage to lungs exceeds poisoning risk. Give nothing by mouth in cases of unconsciousness or convulsion. Get medical attention immediately and show the container or label.
In case of body contact: Remove contaminated clothing. Wash contaminated clothing before reusing.
Self-protection of the first-aiders: No action shall be taken involving any personal risk or without suitable training.
Notes to physician: Treat according to symptoms (decontamination, vital functions), no known specific antidote.

Fire-fighting measures

Suitable extinguishing media: Water spray, carbon dioxide, dry chemical powder, or appropriate foam.
Extinguishing media which must not be used for safety reason: High volume water jet.
Special hazards arising from the substance or mixture: Emits toxic fumes under fire conditions.
Advice for fire-fighters: Wear full protective clothing. Wear self-contained breathing apparatus.
Hazard decomposition products:Carbon dioxide and carbon monoxide, nitrogen & sulfur oxides or morpholine may form when heated to decomposition or in a fire involving this chemical.
Other information: Do not enter fire area without proper protection. Fight fire from safe distance/protected location. Apply aqueous extinguishing media carefully to prevent frothing/steam explosion. Use water spray for cooling. Avoid contact with molten product to prevent serious burns. Avoid raising powdered materials into airborne dust, creating an explosion hazard. Prevent fire-fighting water from entering surface water or groundwater. Contaminated water from fire hoses or sprinkler etc must be prevented from draining into watercourses, sewers or the ground water. Sufficient measures must be taken to retain water used for extinguishing. Contaminated water and soil must be disposed of in conformity with local regulations. Notify authorities if liquid enters sewer/public waters.

Accidental release measures

Personal precautions, protective equipment and emergency procedures: No action shall be taken involving any personal risk or without suitable training. Remove all sources of ignition. Ventilate area of leak or spill. Evacuate surrounding areas. Keep unnecessary and unprotected personnel from entering. Do not touch or walk through spit material. Provide adequate ventilation. Wear appropriate respirator when ventilation is inadequate. Avoid inhalation of dust. Avoid contact with eyes and prolonged skin contact. Put on appropriate personal protective equipment.
Environmental precautions: Do not flush into surface water, sanitary sewer or ground water system. Spillages or uncontrolled discharges into watercourses must be IMMEDIATELY alerted to the Environmental Agency or other appropriate regulatory body.
Methods and material for containment and cleaning up Spills/Leaks: Remove unnecessary people. Clean up spills in a manner that does not disperse dust into the air. Avoid raising dust. Use mechanical handling equipment. Collect the spilled product into suitable containers which must be tightly sealed and properly labelled. Precautions if chemical is spilled or released:Released material poses a dust explosion hazard if it becomes airborne in the presence of an ignition source. Extinguish all ignition sources. On land sweep/shovel into suitable disposal containers or vacuum using equipment which avoids ignition risk. Avoid making dust. On water, contain/minimize dispersion/collect. Report per regulatory requirements.

Handling and storage

Precautions for safe handling: As a general rule,
- not to eat, drink and smoke in work areas ;
- to wash hands after use and;
- to remove contaminated clothing and protective equipment before entering eating areas.
In accordance with good industrial practice, handle with care and avoid unnecessary personal contact. Avoid generation of dusts. Avoid skin and eye contact. Provide good ventilation. Keep away from ignition sources. Handle according to industrial hygiene principles and relevant legal provisions.
For optimum results, use within 6 months of receipt. This chemical is not expected to present an explosion hazard during normal transportation and storage operations. However, when dispersed in air and subject to sufficient energy of ignition, it may pose a dust explosion hazard. Minimize the energy of ignition, it may pose a dust explosion hazard. Minimize the potential for dust explosion by eliminating/controlling ignition sources (bond and ground), and by using good housekeeping practices during storage, transfer, handling and use to avoid excessive dust accumulation.
Containers of this chemical may be hazardous when empty since they retain product residues (dust, solids); observe all warnings and precautions listed for the product.
Handling requirement: DANGER! Toxic for the health. Dangerous for the environment. Handle and open container with care. Do not get in eyes/, on skin/clothing. Avoid dust formation and ignition source. Do not inhale dusts. Do not taste/ingest. Ensure good local exhaust ventilation. Do not eat, drink or smoke at the workplace.
Fire and explosion hazard: When mixed with air and exposed to an ignition source, sufficient dust may become an explosion hazard. Use good housekeeping practices to avoid rendering dust airborne and prevent electrostatic charge formation during transfer and use of this chemical. Ensure that all equipment and containers are adequately grounded. Vapours generated from overheating/decomposition may be flammable and may cause fire/explosion if source of ignition is present. Protection against fire and explosion.
Condition and materials to avoid: Direct sunlight, excessive light, moisture, oxidizing conditions, excessively high temperatures, sparks and open flame, dusting conditions.
Conditions for safe storage, including any incompatibilities: Keep container tightly closed in a dry, cool and well-ventilated place against strong oxidizers when not in use and during transport, prevent contamination with foreign materials. Keep chemical away from direct sunlight, heat, sparks, open flame and other ignition sources. Keep away from food and drink. Store in the original container securely closed. Protect from moisture and physical damage.
Risk of explosion if an air-dust mixture forms. Avoid creating dusty conditions. Empty only into earthed containers. If container is larger than 2000 litre in volume or when flammable solvents are present inert container or use a system otherwise designed to prevent or contain an explosion - seek expert advice.
Specific end uses(s): No specific information.

Transport information

Land transport (ADR/RID)

UN number:
3077
Proper shipping name and description:
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
Chemical name:
2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
Language:
English
Class:
9
Packaging group:
III
Labels:
9
SpecialProvisionsopen allclose all

Inland waterway transport (ADN(R))

UN number:
3077
Shippingopen allclose all
Class:
9
Packaging group:
III
Labels:
9
Remarksopen allclose all

Marine transport (IMDG)

UN number:
3077
Proper shipping name and description:
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
Chemical name:
2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
Class:
9
Packaging group:
III
EmS code:
F-A, S-F
Labels:
9
Marine pollutant
Remarksopen allclose all

Air transport ICAO/IATA

UN number:
3077
Proper shipping name and description:
ENVIRONMENTALLY HAZARDOUS SUBSTANCE, SOLID, N.O.S. 2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
Chemical name:
2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
Class:
9
Packaging group:
III
Labels:
9
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

Control parameters:
WORKER, SYSTEMIC EFFECTS
- DNEL (acute, inhalation) : 5.38 mg/m3/kg (8h)
- DNEL (acute, dermal): 20 mg/kg bw/day
- DNEL (acute, oral) : 19.84 mg/kg bw
- DNEL (long-term, dermal): 0.18 mg/kg bw/day
- DNEL (long-term, inhalation): 0.32 mg/m3

GENERAL POPULATION, SYSTEMIC EFFECTS
- DNEL (long-term, dermal): 0.09 mg/kg bw/day
- DNEL (long-term, inhalation): 0.16 mg/m3
- DNEL (long-term, oral): 0.05 mg/kg bw/day
A summary of the risk management measures that adequately control exposure of the human health and environment to the chemical is given for the exposure scenarios set out in the annex:
Exposure controls
Appropriate engineering controls: Work in well ventilated areas. Local exhaust ventilation is generally required because it can control the emissions of the contaminant and its source, preventing dispersion of it into the general work area.
Individual protection measures, such as personal protective equipment
Precautionary and hygiene measures: Precautionary measures: Do not handle this chemical near heat, sparks or open flame. Prevent electrostatic discharge formation. Avoid accumulation of dust in enclosed space. Keep container closed when not in use. Avoid contact with eyes, skin and clothing. Do not breathe dust. Use only with adequate ventilation / personal protection. Before using this chemical or products containing this chemical, read EESDS. Hygiene measures:Wash hands, forearms and face thoroughly after handling this chemical or products containing this chemical, before eating, smoking and using the lavatory and at the end of the working period. Appropriate techniques should be used to remove potentially contaminated clothing. Wash contaminated clothing before reusing. Do not eat, drink or smoke while working. Keep away from foodstuffs, beverages and food. During synthesis, formulation or application, follow good industrial hygiene practice. Emergency eye wash fountains and safety showers should be available in the immediate vicinity of any potential exposure.
Respiratory protection: Use NIOSH/MSHA approved respirator or dust mask if airborne particulate is generated when handling this chemical. High levels of protection would also be required for laboratory workers handling the chemical.
Hand protection: Protective gloves (impervious gloves) should be worn at all times when handling chemical products. PVC coated cotton gloves and/or heavy rubber gloves are recommended.
Eye protection: Use chemical safety goggles and/or full face shield where dusting or splashing of solutions is possible. Dust service goggles should be worn to prevent mechanical injury to eyes due to airborne particles which may be associated with this chemical. Maintain eye wash fountain and quick-drench facilities in work area.
Skin protection: Wear impervious protective clothing, including boots, gloves, lab coat, apron or coveralls, as appropriate, to prevent skin contact. The skin protection equipments should be cleaned thoroughly after each use.
Body protection:Wear overall, protective clothing, e.g. wear rubber apron, wear rubber footwear/boots.
Environmental exposure control: This chemical is toxic to aquatic life with long lasting effects. Do not allow this chemical or products containing this chemical or contaminated containers to enter drains, sewers or water courses. Do not allow to directly enter the environment. Any potential releases to air, water or soil should be avoid.
- PNEC (aqua, freshwater): 0.0012 mg/l
- PNEC (aqua, marine water): 0.00012 mg/l
- PNEC (aqua, intermittent releases): 0.012 mg/l
- PNEC (STP): 1 mg/l
- PNEC (sediment, freshwater): 0.0174 mg/kg sediment bw (in case of log Koc = 2.8, OECD 121, 1988)
- PNEC (sediment, marine water): 0.00174 mg/kg sediment bw (in case of Log Koc = 2.8, OECD 121, 1988)
- PNEC (soil): 0.081 mg/kg soil dw (in case of Log Koc = 2.8, OECD 121, 1988)

Stability and reactivity

Reactivity: No specific information
Chemical stability: Stable under ordinary conditions of use and storage. Heat will contribute to instability.Decomposition temperature: > 200 °C
Possibility of hazardous reactions:No hazardous reactions known.
Conditions to avoid: Heat, ignition sources and incompatibilities. Static discharges.
Incompatible materials:Strong acids, strong bases and strong oxidising agents.
Hazardous decomposition products: Carbon dioxide and carbon monoxide, nitrogen & sulfur oxides or morpholine may form when heated to decomposition or in a fire involving this chemical.
10.7 Further information: Will not occur.

Disposal considerations

Waste treatment methods: The generation of waste should be avoided or minimised wherever possible. Disposal of this substance or product containing this chemical, solutions and any by-products must be dumped or incinerated in accordance with local/regional/national/international regulations.
Waste from residues/unused products: Residual chemical should be disposed by incineration or by other modes or disposal in compliance with local/regional/national/international regulations.
Contaminated packaging: Contaminated packaging material should be treated equivalent to residual chemical. Clean packaging material should be subjected to waste management schemes (recovery recycling, reuse) according to local/regional/national/international regulations.
Hazardous waste: -
Recommendation: Released material poses a dust explosion hazard