Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
no data
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Test compliant with GLP and Guideline OECD 402

Data source

Reference
Reference Type:
other: Body responsible for the test
Title:
Unnamed
Year:
1988

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
not specified
GLP compliance:
yes
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
EC Number:
400-600-6
EC Name:
2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one
Cas Number:
71868-10-5
Molecular formula:
C15H21NO2S
IUPAC Name:
2-methyl-1-(4-methylthiophenyl)-2-morpholinopropan-1-one

Test animals

Species:
rat
Strain:
other: Tif: RAI f (SPF)
Sex:
male/female

Administration / exposure

Type of coverage:
semiocclusive
Vehicle:
other: none
Duration of exposure:
24 h
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Mortality:
Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mglkg bw; Number of animals: 5; Number of deaths: 0
Clinical signs:
Signs of toxicity related to dose levels:
Common symptoms in acute tests (piloerection, abnormal body position and dyspnea).
All animals recovered within 7 days.
Gross pathology:
Effects on organs:
none
Other findings:
Signs of toxicity (local):
None

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: EU