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EC number: 618-837-0 | CAS number: 92339-11-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to reproduction: other studies
Administrative data
- Endpoint:
- toxicity to reproduction: other studies
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02.06.1989-05.01.1990
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study meets the requirements of the OECD Principles of Good Laboratory Practice, Paris, 1992
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- The effects of iodixanol on peri- and post-natal development was studied in the rat. Daily dosages of 0 (saline control), 0.3, 1.0 and 2.0 gI/kg/day were administered via the lateral tail vein to groups of 25 time-mated female rats from day 17 of pregnancy to day 21 postpartum, inclusive. The females were allowed to litter and rear their young to weaning, when selected offspring were retained and assessed for behavioural and reproductive performance. Twenty Fl females originating from each group were paired with 20 F1 males originating from the same group and allowed to litter and rear their young (F2 generation) to weaning. Kidney weights were recorded for F0 and F1 adults.
- GLP compliance:
- yes
- Type of method:
- in vivo
Test material
Reference
- Name:
- Unnamed
- Type:
- Constituent
Test animals
- Species:
- rat
- Strain:
- Crj: CD(SD)
- Sex:
- female
Administration / exposure
- Route of administration:
- intravenous
- Duration of treatment / exposure:
- Daily dosages of 0 (saline control), 0.3, 1.0 and 2.0 gI/kg/day were administered via the lateral tail vein to groups of 25 time-mated female rats from day 17 of pregnancy to day 21 postpartum, inclusive.
- Frequency of treatment:
- Daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:0 (saline control), 0.3, 1.0 and 2.0 gI/kg/day Basis:
- No. of animals per sex per dose:
- F0: Female: 25F1: Male 20 and Female 20
- Control animals:
- yes
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Remarks on result:
- not determinable
- Remarks:
- no NOAEL identified
Observed effects
Applicant's summary and conclusion
- Conclusions:
- Treatment of F0 females did not adversely affect the performance of untreated F1 offspring in specific behaviour tests, mating performance, pregnancy rate, duration of pregnancy or overall ability to rear F2 offspring to weaning.
- Executive summary:
The effects of iodixanol on peri- and post-natal development was studied in the rat. Daily dosages of 0 (saline control), 0.3, 1.0 and 2.0 gI/kg/day were administered via the lateral tail vein to groups of 25 time-mated female rats from day 17 of pregnancy to day 21 postpartum, inclusive. The females were allowed to litter and rear their young to weaning, when selected offspring were retained and assessed for behavioural and reproductive performance. Twenty Fl females originating from each group were paired with 20 F1 males originating from the same group and allowed to litter and rear their young (F2 generation) to weaning. Kidney weights were recorded for F0 and F1 adults.
Treatment of parental F0 females with 2.0 gI/kg/day iodixanol was associated with increased kidney weights, transient reddening of the pinnae post dosing, slightly reduced food consumption during lactation, and slight, but not statistically significant reduction in litter and pup mean weights through weaning. Increased kidney weight was also apparent in the 1.0 gI/kg/day dosage group. Treatment with 0.3 or 1.0 gI/kg/day iodixanol resulted in no other toxicologically important effects.
Mean weekly body weights for male and female F1 adults derived from dams treated with 2.0 gI/kg/day, and for F1 males from dams treated at 1.0 gI/kg/day, were slightly lower than controls. Mean pup weights on days 12 and 21 were marginally reduced for animals derived from the 0.3 and 1.0 gI/kg/day dosage groups, which was probably related to the slightly larger litter sizes. None of these differences from control values were statistically significant.
In summary, treatment of F0 females did not adversely affect the performance of untreated F1 offspring in specific behaviour tests, mating performance, pregnancy rate, duration of pregnancy or overall ability to rear F2 offspring to weaning.
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