Registration Dossier

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

Currently viewing:

Administrative data

Link to relevant study record(s)

Description of key information

Significant accumulation in organisms is not to be expected.

Key value for chemical safety assessment

BCF (aquatic species):
3.2 L/kg ww

Additional information

Based on the measured log Kow of 0.83 (BASF AG, 1989; report no. BRU 89.099), no bioaccumulation of cyclopentylamine is expected. In accordance with column 2 of REACH Annex IX, a study does not need to be conducted since the substance has a log Kow less or equal than 3.

The BCF of cyclopentylamine is estimated in a weight-of-evidence approach using different QSAR calculation models (BASF SE, 2012/13): - BCFBAF v3.01 of EPI Suite v4.10 calculated a log BCF of 0.50 (BCF: 3.2 L/kg ww) - US EPA TEST v4.1 estimated a log BCF of 0.35 (BCF: 2.24 L/kg ww) using the consensus method - VEGA Read-across model v1.0.2 predicted a log BCF of 0.29 (BCF: 2 L/kg) - VEGA Meylan model 1.0.2 predicted a log BCF of 0.42 (BCF: 3 L/kg) Since the BCFBAF model estimated the highest BCF value of 3.2, signficant accumulation in organisms is not to be expected.