Registration Dossier
Registration Dossier
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EC number: 938-702-2 | CAS number: -
Endpoint summary
Administrative data
Description of key information
In the OECD 423-study the dosis letalis media (LD50) to rats of Cyclohexanol, 4-C11-12-alkyl, branched was found to be > 2000 mg/kg bodyweight.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Additional information
In a reliable (Klimisch 1) GLP compliant OECD 423 guideline study (Acute toxic class method) Cyclohexanol, 4 -C11 -12 -alkyl, branched was assessed for oral toxicity in female rats. No animal died. The median lethal dose of Cyclohexanol, 4 -C11 -12 -alkyl, branched after a single oral administration to female rats, observed over a period of 14 days is LD50 > 2000 mg/kg. At a dose of 300 mg/kg bw/d after 2 h 3 animals showed slight piloerection. At 2000 mg/kg bw/d after 30 minutes there were no signs of toxicity, after 2 and 3 hours slight piloerection was seen in all six animals, 3 animals showed slightly reduced spontaneous activity and bradykinesia after 4 hours, after 5 hours the 3 animals showed moderately reduced spontaneous activity and moderate piloerection and day 2 until the end of the observation period no signs of toxicity were seen in all animals. None of the animals showed weight loss during the observation period.
Justification for classification or non-classification
Cyclohexanol, 4-C11-12-alkyl, branched based on the available acute toxicity information does not present an acute oral toxicity hazard and does not require classification according Regulation (EC) No 1272/2008.
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