Registration Dossier

Administrative data

Key value for chemical safety assessment

Additional information

Acemetacin-tert.-butylester was shown to be not mutagenic with and without metabolic activation in the S. typhimurium strains TA 1535, TA 100, TA 1537 and TA 98. The study was conducted using the plate incorporation method with substance concentrations from 20 to 12500 µg per plate.


Short description of key information:
Gene mutation in vitro (bacterial reverse mutation assay, GLP): negative in the tested Salmonella typhimurium strains TA 1535, TA 100, TA 1537 and TA 98
[Bayer AG, Report No. 15913, 1987-07-07]

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

Classification according to Directive 67/548/EEC and Regulation (EC) No. 1272/2008 (CLP) is not required.