Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 616-210-6 | CAS number: 75302-98-6
Clinical signs at 50 mg/kg and above included piloerection, nasal discharge, bloody muzzle, increased salivation, paleness, sunken flanks, sedation, laboured breathing and emaciation. Onset of symptoms was 1 h after administration, on day 13 signs had disappeared.
No symptoms occurred in males after dosage with 25 mg/kg. One female showed slight to moderate salivation lasting about 1 day after administration and ruffled fur.
The surviving animals of the 50 mg/kg dose group showed a significant reduction of body weight during the first week.
Death occurred from day 2 until day 9. Necropsy of dead animals showed findings including abdominal cavity filled with serous liquid, abdominal organs with multiple adhesions and fibrinoid coatings. No findings were observed at final necropsy.
The acute oral toxicity of Acemetacin-tert.-butylester was determined in male and female rats after single administration of six concentrations with an application volume of 10 ml/kg via stomach tube with an observation period of 14 d.
The acute oral LD50 for males was 67 mg/kg and for females > 25 < 50 mg/kg. The LD50 for both sexes is approximately 36 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again