Registration Dossier
Registration Dossier
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EC number: 248-096-5 | CAS number: 26896-48-0
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish
In a pre-guideline study using a method comparable to OECD test guideline 203 with octahydro-4,7-methano-1H-indenedimethanol (TCD-Alcohol DM) as test substance, short term toxicity to fish was tested for four different fish species (Hollander/Hoechst AG, 1976; statistically re-evaluated by OXEA, 2015 ). The LC50 values determined ranged from 100.3 mg/L (Oncorhynchis mykiss) to 175.3 mg/L (Lepomis gibbosus).
Long term toxicity to fish
Waiving argument:
The chemical safety assessment of octahydro-4,7-methano-1H-indenedimethanol (TCD-Alcohol DM) does not reveal a need to classify the substance as dangerous to the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment.
Therefore and for reasons of animal welfare, a long-term toxicity test on fish is not provided.
Short-term toxicity to aquatic invertebrates
The short-term toxicity of octahydro-4,7-methano-1H-indenedimethanol (TCD-Alcohol DM) to aquatic invertebrates was tested in a GLP study with Daphnia according to OECD test guideline 202. The EC50 was determined to be > 100 mg/L. No effects on mobility were observed at this concentration (highest concentration tested). The study is acceptable satisfying guideline requirements.
Long term toxicity to aquatic invertebrates
Waiving argument:
The chemical safety assessment of octahydro-4,7-methano-1H-indenedimethanol (TCD-Alcohol DM) does not reveal a need to classify the substance as dangerous to the environment, nor is it a PBT or vPvB substance, nor are there any further indications that the substance may be hazardous to the environment.
Therefore, a toxicity test on aquatic invertebrates is not provided.
Toxicity to aquatic algae and cyanobacteria
The toxicity of octahydro-4,7-methano-1H-indenedimethanol (TCD-Alcohol DM) to aquatic algae and cyanobacteria was tested in a GLP study with green algae (Pseudokirchnerella subcapitata) according to OECD test guideline 201. The ErC50 was determined to be > 100 mg/L (highest concentration tested). The NOEC was 100 mg/L. The study is acceptable satisfying guideline requirements.
Toxicity to microorganism
The toxicity of octahydro-4,7-methano-1H-indenedimethanol (TCD-Alcohol DM) to microorganisms was tested under GLP conditions in an activated sludge respiratory inhibition study according to OECD test guideline 209. The EC50 was determined to be 2400 mg/L. The NOEC was 440 mg/L. The study is acceptable satisfying guideline requirements.
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