Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study obtained through inquiry process; SNIF file obtained from ECHA.

Data source

Reference
Reference Type:
other: SNIF
Title:
Unnamed
Year:
1993

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
not specified
Qualifier:
according to guideline
Guideline:
EU Method C.1 (Acute Toxicity for Fish)
Deviations:
not specified
GLP compliance:
yes

Test material

Constituent 1
Reference substance name:
Body responsible for the test
IUPAC Name:
Body responsible for the test
Test material form:
not specified

Sampling and analysis

Analytical monitoring:
not specified

Test solutions

Vehicle:
yes
Details on test solutions:
3.56 mg/L Alkylphenol-polyglycolether

Test organisms

Test organisms (species):
other: zebra fish

Study design

Test type:
semi-static
Water media type:
freshwater
Total exposure duration:
96 h

Test conditions

Hardness:
184 mg CaCO3/L

Results and discussion

Effect concentrationsopen allclose all
Duration:
24 h
Dose descriptor:
LC50
Effect conc.:
> 9.2 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
> 9.2 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
72 h
Dose descriptor:
LC50
Effect conc.:
> 9.2 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 9.2 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
9.2 mg/L
Nominal / measured:
meas. (not specified)
Conc. based on:
test mat.
Basis for effect:
not specified
Details on results:
%Concentration loss over test: 28 ... 90
The values based on actual end concentrations.
No mortality and no effects were observed at the maximum achievable concentration. Therefore no classification necessary. Values are based on measured concentrations at 96h exposure.

Applicant's summary and conclusion

Validity criteria fulfilled:
not specified
Conclusions:
LC50 (96h) > 9.2 mg/L
NOEC (96h) = 9.2 mg/L;
Due to its very low water solubility (see IUCLID section 4.8), the test substance is considered not to be toxic to fish under the conditions of the test.
Executive summary:

The acute toxicity of the test substance to fish has been determined in a test with zebra fish according to OECD Guideline 203 and EU Method C.1. The LC50 (96h) was > 9.2 mg/L and the NOEC (96h) was = 9.2 mg/L. No mortality and no effects were observed in the range of the low water solubility of the test substance. Therefore, the test substance is considered not to be harmful to fish.

Categories Display