Registration Dossier
Registration Dossier
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EC number: 412-770-9 | CAS number: 12141-67-2 NATRIUMMETAWOLFRAMAT
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Directive 84/449/EC, B.14, Ames test
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Hexasodium tungstate hydrate
- EC Number:
- 412-770-9
- EC Name:
- Hexasodium tungstate hydrate
- Cas Number:
- 12141-67-2
- Molecular formula:
- Na6 H2 W12 O40 . xH2O
- IUPAC Name:
- hydrate hydrogen oxygen sodium hydride tungsten
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with and without
- Metabolic activation system:
- S9 liver microsomal fraction of rats treated with Aroclor 1254
- Test concentrations with justification for top dose:
- Concentration range in the main test (with metabolic activation): 10 - 5000 µg/plate
Concentration range in the main test (without metabolic activation): 10 - 5000 µg/plate - Vehicle / solvent:
- Solvent: bidest. water
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- with
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 µg/plate)
- Species / strain:
- S. typhimurium TA 1535, TA 1537, TA 98 and TA 100
- Metabolic activation:
- without
- Genotoxicity:
- not specified
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- (> 5000 µg/plate)
- Remarks on result:
- other: other: preliminary test
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
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