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Diss Factsheets

Physical & Chemical properties

Water solubility

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
27 Jun - 19 Jul 2001
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
92/69
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method
Key result
Water solubility:
16.9 g/L
Conc. based on:
test mat. (dissolved fraction)
Temp.:
20 °C
pH:
3
























Target condition according to 


guideline: 



Actual condition according to 


the study: 



Validity criteria met: 



A substance-specific analytical method is preferred for these determinations, since small amounts of soluble 


impurities can cause large errors in the measured solubility. Examples of such methods are: gas or liquid 


chromatography, titration methods, photometric methods, voltametric methods. 



The study was analytically monitored via HPLC. 



yes 



The pH of each sample should be recorded. 



For each sample the pH value is reported. 



yes 



The individual results from each of the three flasks, which should not differ by more than 15%, are averaged. 



The largest deviation from the mean value 16.9 g/mL is +/- 0.1 g/mL. 



yes 


Conclusions:
The water solubility of the test substance is 16.9 g/L at 20°C.
Executive summary:

In a GLP study according to 92/69/EEC Method A.6, the water solubility of the test substance was determined using the shake flask method. The study was analytically monitored via HPLC. The water solubility of the test substance is 16.9 g/L at 20°C.

Description of key information

In a GLP study according to 92/69/EEC Method A.6, the water solubility of the test substance was determined using the shake flask method. The study was analytically monitored via HPLC. The water solubility of the test substance is 16.9 g/L at 20°C.

Key value for chemical safety assessment

Water solubility:
16.9 g/L

Additional information