Registration Dossier

Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: 4e The study did not meet current guideline requirements for OECD 405. It does, however, add weight of evidence for eye irritation.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1951
Report Date:
1951

Materials and methods

Principles of method if other than guideline:
No data
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
- Name of test material (as cited in study report): Dichlorodimethylsilane
No further details available

Test animals / tissue source

Species:
rabbit
Strain:
not specified

Test system

Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
0.005 ml
Duration of treatment / exposure:
No data
Observation period (in vivo):
No data
Number of animals or in vitro replicates:
No data

Results and discussion

Any other information on results incl. tables

Grade >5 indicating corneal burns from 0.005 ml of test substance.

Applicant's summary and conclusion

Conclusions:
In a non-guideline, pre-GLP, eye irritation study (reliability score 4) 0.005 ml of dichlorodimethylsilane caused corneal burns to rabbit eyes.
Executive summary:

In a non-guideline, pre-GLP, eye irritation study (reliability score 4) 0.005 ml of dichlorodimethylsilane caused corneal burns to rabbit eyes.