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EC number: 700-717-5 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 08.08.1989 to 22.08.1989
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: 1a The study was conducted according to the appropriate OECD test guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Needs proper translation as key study
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- Dichloro(dimethyl)silane
- EC Number:
- 200-901-0
- EC Name:
- Dichloro(dimethyl)silane
- Cas Number:
- 75-78-5
- Molecular formula:
- C2H6Cl2Si
- IUPAC Name:
- Dichloro(dimethyl)silane
- Details on test material:
- - Name of test material (as cited in study report): Dimethyldichlorsilan
- Substance type: chlorosilane
- Physical state: Colourless liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann, Borchen
- Age at study initiation: 7-10 weeks
- Weight at study initiation: Average maximum weights: Males 174 g; females 167 g
- Fasting period before study:
- Housing: Type III Macrolon cages (5 per cage)
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: Four days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22± 2
- Humidity (%): 50±10
- Air changes (per hr): approximately 10
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: Not clear - needs translation
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- paraffin oil
- Details on oral exposure:
- VEHICLE - might be more information, but cannot translate
- Concentration in vehicle: No data
- Amount of vehicle (if gavage): No data
- Justification for choice of vehicle: No data
- Lot/batch no. (if required): No data
- Purity: No data
MAXIMUM DOSE VOLUME APPLIED: 10 ml/kg bw
DOSAGE PREPARATION (if unusual): Not clear from German report - Doses:
- 125, 500, 707 and 1000 mg/kg bw
- No. of animals per sex per dose:
- Five
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Observed twice daily, body weights measured before dosing, and on day 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed:gross examinations performed
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 595 mg/kg bw
- Mortality:
- All animals in the 1000 mg/kg bw group died approximately one hour after application. After 707 mg/kg bw animals died between three hours and five days. No animals died in the 125 and 500 mg/kg bw group.
- Clinical signs:
- other: Clinical signs for the 500 and 707 mg/kg bw were ruffled coat and general poor condition. At 1000 mg/kg bw rats showed ruffled fur, laboured breathing and sedation. The symptoms were mild to moderate, occurred approximately 30 minutes after dosing, and la
- Gross pathology:
- Gastrointestinal tract dark red or black, red pancreas, brown mottled liver in the 707 and 1000 mg/kg bw.
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- In an acute oral toxicity study (reliability score 1) conducted to the now deleted OECD 401 and GLP, the LD50 for dichloro(dimethyl)silane was 595 mg/kg bw in rats.
- Executive summary:
In an acute oral toxicity study (reliability score 1) conducted to the now deleted OECD 401 and GLP, dichloro(dimethyl)silane (in paraffin oil) was administered by oral gavage to Wistar rats (five/sex/dose) at doses of 125, 500, 707 and 1000 mg/kg bw. Animals were then observed for 14 days, twice daily. Body weights were measured before dosing, and on days 7 and 14. All animals were examined macroscopically. All animals in the 1000 mg/kg bw group died approximately one hour after application. After 707 mg/kg bw animals died between three hours and five days. No animals died in the 125 and 500 mg/kg bw group. Clinical signs for the 500 and 707 mg/kg bw were ruffled coat and general poor condition. At 1000 mg/kg bw rats showed ruffled fur, laboured breathing and sedation. The symptoms were mild to moderate, occurred approximately 30 minutes after dosing, and lasted for up to three days or until death. After 125 mg/kg bw ruffled fur was the only clinical sign observed. All surviving animals were asymptomatic by day 4. Necropsy revealed dark red or black gastrointestinal tract, red pancreas, brown mottled liver in the 707 and 1000 mg/kg bw. The LD50 was calculated to be 595 mg/kg bw.
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