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Physical & Chemical properties

Water solubility

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Administrative data

water solubility
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
January 18, 2008 - January 24, 2008
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Test substance is hydrolytically unstable; water solubility test is not feasible.

Data source

Reference Type:
study report
Report date:

Materials and methods

Test guideline
no guideline followed
Principles of method if other than guideline:
The test substance was prepared in 1 wt% in water and saturated sample was analyzed by GC with an Electron Capture Detector.
GLP compliance:
Type of method:
other: capillary gas chromatography

Test material

Constituent 1
Reference substance name:
Details on test material:
- Name of test material (as cited in study report): MeDONA
- Substance type: single-constituent substance
- Physical state: Clear and colorless liquid
- Analytical purity: 98.9%
- Purity test date: 2/17/2009
- Lot/batch No.:NB 140499-21-8
- Expiration date of the lot/batch :08/25/2014
- Stability under test conditions: Stable
- Storage condition of test material: Frozen

Results and discussion

Water solubility
Water solubility:
4.38 mg/L
Details on results:
The water solubility of MeDONA in water was determined to be 4.38 mg/L at 23 °C. Only one sample was prepared and analyzed.

Any other information on results incl. tables

The pH of 1% MeDONA solution is 5.3±0.3.

Applicant's summary and conclusion

MeDONA had a water solubility of 4.38 mg/L at 23 °C.
Executive summary:

The water solubility of MeDONA in water was prepared in 1 wt% in water and shaken for one hour. The saturated sample was centrifuged and the clear aqueous phase was analyzed by GC/ECD. MeDONA had a water solubility of 4.38 mg/L at 23 °C from a single measurement. Since MeDONA has a hydrolytic half-life of 2.68±1.63 minutes in neutral water and a half life of 52.5 ± 1.99 minutes at pH 2 water. As such, experimental measurement of water solubility is not feasible. Therefore, this data is considered not reliable.