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Diss Factsheets
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EC number: 206-575-6 | CAS number: 355-04-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Not believed to bioaccumulate.
The only specific testing for perfluorocarbons that we are aware of was performed by "Chemical Biotesting Centre" in Japan in 1984 on perfluoroperhydrophenanthrene (bp 215°C) (testing performed on carp, and using a surfactant, HCO-20 or F-142D, to aid dissolution, over 8 weeks).
Concentration | BCF (weighted averages) |
1 mg/l | 0.2 - 4.7 |
0.1 mg/l | 7.3 - 30 |
However, use of perfluorocarbons (particularly octafluoropropane, perfluoro-2 -methylhexane, perfluorooctane and perfluorodecalin) in medical applications strongly supports the claim that these materials as a class are not bioaccumulated.
Testing of blood extenders (red cell substitutes) in the 1970s, in which the perfluorocarbon is injected into the blood stream in the form of an emulsion, indicates that they are removed via transpiration and respiration through the skin and lungs. They remain in the spleen and liver for longer, but are eliminated after some weeks. Higher boiling perfluorocarbons seem to be retained longer, so perfluorodecalin (bp 142°C) is eliminated after 4 weeks, while perfluoromethyldecalin (bp 160°C) is retained significantly longer (K Yokoyama et al., Fed. Proc., 34(6), 1975, 1478-83).
"The generality that compounds containing only carbon and fluorine are superior because they do not remain indefinitely in the liver and spleen has also emerged." LC Clark et al., Fed. Proc., 34(6), 1975, 1468-77.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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